Poster #16: William Steiner – Regulation of Protein Complexes During Hedgehog Signal Transduction

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Faculty mentor: Benjamin Myers

I used bioluminescence resonance energy transfer (BRET) to investigate interactions between different proteins in the Hedgehog (Hh) pathway. I focused on Kif7 and SuFu interactions with the GPCR Smoothened (SMO) and PKA-C. Kif7 is analogous to Cos2 in fruit flies. Cos2 scaffolds the GLI transcription factor and PKA-C. I suspect that Kif7 may play a similar role. Kif7 and SuFu may also play a role in PKA-C binding to SMO.

Click below to hear me present my poster!
Questions or comments? Contact me at: u1000400@utah.edu

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