Faculty mentor: Aaron Puri
Methane-oxidizing bacterium Methylobacter tundripaludum makes a natural product that inhibits the growth of the model yeast Saccharomyces cerevisiae.Genetic studies and analytical chemistry strongly suggest this compound is a microsclerodermin.Our results from the project show that yeast in log phase are much more susceptible to the compound than stationary phase cells. The result supports the hypothesis that the microsclerodermins have a specific molecular target worthy of further investigation
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