Poster #19: Eshan Narasipura – Full Synthesis of Enzymatically Cleavable Linker Between 929-Designed Ankyrin Repeat Protein And 17-Dimethlyamino Geldanamycin

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Faculty mentor: Shawn Owen

An enzymatically cleavable linker was synthesized to conjugate 17-Dimethylamino Geldanamycin (DMAG) and 929 designed ankyrin repeat protein (929-DARPin) where DMAG was used to inhibit the route of endosomal recycling, and 929-DARPin used as the ligand to bind to HER-2. We will be able to co-dose 929DARPin-DMAG and TDM-1 in order to see the changes in efficacy of TDM-1 as well as explore other linker applications to overcome drug resistance.

Click below to hear me present my poster!
Questions or comments? Contact me at: eshan.narasipura@utah.edu

 

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