Faculty mentor: Aaron Puri
Bacteria utilize signaling molecules called acyl-homoserine lactones (acyl-HSLs) to monitor their population densities and regulate group behaviors. These signals can be produced through a coenzyme-A (CoA) utilizing pathway, but it is difficult to predict what substrates bacteria need to produce these signals from synthase sequence alone. We hypothesize that analyzing the co-occurrence of CoA ligases and acyl-HSL synthases will allow for the prediction of what substrates these pathways use.
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