Oral #13: Katerina Excell – The role of Amyloid Precursor Protein in a model of Alzheimer’s Disease

<< Return to the Virtual URS Main Page

Faculty mentor: Villu Maricq

Alzheimer’s disease (AD) is a devastating disorder that leads to deterioration of cognition and memory. The prevalence of AD rises with age, and is also greater in individuals with trisomy 21. We have modeled the overexpression of APP in transgenic C. elegans to gain new insights into the pathophysiology of AD. We found that motor-mediated transport of AMPA-type ionotropic glutamate receptors and glutamate-gated currents were severely disrupted, leading to altered behavior of the animals.

Watch my research presentation below.
Questions or comments? Contact me at: u1195036@utah.edu

View my Presentation Slides HERE

<< Return to the Virtual URS Main Page