Faculty mentor: Yan-Ting Shiu
The arteriovenous fistula (AVF) is the most common and preferred vascular access type for hemodialysis (HD) patients with end-stage kidney disease (ESKD). However, up to 60% of AVFs fail to mature and achieve the high blood flow rate required for HD cannulation due to neointimal lesion formation and impaired lumen expansion. This study investigates the effect of inhibiting receptors for advanced glycation end products (RAGE) on neointimal lesion development in AVF remodeling and maturation.
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