Faculty mentor: Michael Yu
Neovascular Age-Related Macular Degeneration is a chronic eye disease caused by over-expression of VEGF and treated with eye injections of VEGF-binding Ranibizumab (fab). The fab’s short ocular half-life leads to poor patient compliance. We attached hyaluronic acid (HA) and collagen (col) targeting peptides to the fab to target HA and col in the vitreous. We demonstrated high binding affinity of our conjugates for HA and col as well as VEGF, showing that our conjugates may extend fab half-life.
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