Faculty mentor: Shawn Owen
Epidermal Growth Factor (EGF) increases dimerization and subsequent internalization between cell surface proteins HER2 and HER3. Internalization of HER2 is essential for the mechanism of a targeted drug therapy strategy. Another essential step for this therapy is the translocation of HER2 to the lysosome. While EGF increases internalization, it does not increase lysosomal accumulation of HER2 thus co-treatment with EGF does not improve the efficacy of this targeted drug therapy strategy.
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