Poster #96: David Topham – Investigation of EGF effects on HER2 lysosomal accumulation

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Faculty mentor: Shawn Owen

Epidermal Growth Factor (EGF) increases dimerization and subsequent internalization between cell surface proteins HER2 and HER3. Internalization of HER2 is essential for the mechanism of a targeted drug therapy strategy. Another essential step for this therapy is the translocation of HER2 to the lysosome. While EGF increases internalization, it does not increase lysosomal accumulation of HER2 thus co-treatment with EGF does not improve the efficacy of this targeted drug therapy strategy.

Click below to hear me present my poster!
Questions or comments? Contact me at: davidj.topham@gmail.com

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