Faculty mentor: Minna Roh-Johnson
Cell migration is an important biological process in embryology, wound healing, and cancer. The traditional two-dimensional metastatic model shows that cells utilize focal adhesion complexes to migrate. An important component in forming focal adhesion dynamics is paxillin, a protein that is integral to focal adhesion and is regulated by phosphorylation. I am analyzing the importance of phosphorylated paxillin in in vivo conditions to in vitro conditions on its impact of cell migration rates.
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