Poster #97: Bella Archibald – Human Mutations Linked to Epilepsy Alter Synaptic Vesicle Fusion in C. elegans

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Faculty mentor: Erik Jorgensen

Here, we use CRISPR/Cas9 to develop disease models of epilepsy-causing human mutations in C. elegans. We use these models to determine how each mutation changes the rates of neurotransmission. We postulate that snt-1 binds SNAP-25 at these regions to perform a repressive role in synaptic vesicle fusion. The findings presented here will 1) help physicians make more informed decisions regarding patient therapies and 2) increase the basic scientific understanding of SNAP-25 and snt-1 binding.

Click below to hear me present my poster!
Questions or comments? Contact me at: bellarchibald@gmail.com

 

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